Renal tubular epithelial cell death and cyclosporin A

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Renal tubular epithelial cell death and cyclosporin A.

BACKGROUND The pathogenesis of chronic cyclosporin A (CsA) nephrotoxicity is largely unknown. In this study we examined whether CsA produces cell death through necrosis or apoptosis of either cultured human proximal tubular epithelial cells (PTEC) or the porcine tubular cell line LLC-PK(1). METHODS Primary isolates of human PTEC and LLC-PK(1) cells were treated for various time periods with C...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 2002

ISSN: 1460-2385

DOI: 10.1093/ndt/17.7.1181